New Clinical Insight: HLA-B27 Screening by Flow-Cytometry
Posted by Dr Andrew Botham, September 22, 2010, 3:07 AM
I am excited to present our latest Clinical Insight on HLA-B27 screening by flow-cytometry - available now to download  from our website. ACM Global have recently added this to their in-house testing repertoire and due to the number of blank stares I have received when highlighting this I thought I would provide and brief background, and the significance of this testing. 

The Human Leucocyte Antigen (or HLA) is the name of the Major Histocompatibility Complex in humans (MHC). HLA's are expressing on the surface of most cells and are essentially unique to that individual. HLA's are used by the immune system to differentiate self and non-self cells and when compromised. HLA-B27 is a sub-type of Class I HLA's and is responsible for presenting antigens to T-cells. The HLA-B27 is strongly associated with a certain set of automimmune conditions referred to as "Seronegative spondyloarthropathy", and I'll discuss why the relationship between different diseases and HLA-B27 is yet to be fully understood. 

For those of you still unfamiliar with our Clinical Insight, we produce a series of technical reports, written by our team of experts on different issues affecting clinical testing today. You can download the entire HLA-B27 article here or browse through our previous issues for more central lab services insights. We also encourage you to subscribe to our Clinical Insights to receive them directly in your inbox. 

We look forward to your comments. Please share your insight and expertise on this subject so we can all advance our understanding on HLA-B27!
Category: Clinical Trials Testing
Comments
Keisha Kaleel  11/17/2011 09:08:15 PM
Thank you for providing this article. It is really essential for me.
Ronald  9/24/2011 09:42:06 PM
Much appreciated for the information and share!
Mark Machine  8/19/2011 05:45:06 AM
I learned a lot from this post, great help for me, thank you!
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